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KMID : 0361020000430050501
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Korean Journal of Otolaryngology - Head and Neck Surgery
2000 Volume.43 No. 5 p.501 ~ p.506
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Angiocentric Immunoproliferative Lesions of the Nasal Cavity
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Ye Mi-Kyung
Lee Chul-Hee
Park June-Sik
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Abstract
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Background and Objectives : In the past years angiocentric immunoproliferative lesion
was described as various terms and histologically characterized by polymorphism,
angiodestruction, and necrosis. This study was carried out to analyze the clinical profile,
the results of treatment, and immunohistochemical nature of the angiocentric
immunoproliferative lesion of the nasal cavity. In addition, we aimed to estimate the
significance of Epstein-Barr virus infection as a causative agent in this disease.
Materials and Methods : We performed clinical and pathologic review of patients with
the destructive sinonasal lesions, who were treated at the department of Otolaryngology,
Kyungpook National University. Immunohistochemical staining was done in 28 cases and
EBER in situ hybridization was done in 14 cases.
Results : The overall five-year survival rate was 62%. Immunohistochemical study
showed positive reaction to the T-cell surface marker and Epstein-Barr virus was
detected in all tested cases.
Conclusion : Nasal cavity AIL was non-Hodgkin’s lymphoma, and of T-cell origin, and
was closely related with the Epstein Barr virus infection. It may be worthwhile to
evaluate its pathogenesis in relation with Epstein-Barr virus infection and study the
appropriate treatment method.
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KEYWORD
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Angiocentric immunoproliferative lesion, Non-Hodgkin’s lymphoma, T-cell, Epstein-Barr virus
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